Posted by lucie lu on October 24, 2008, at 18:30:14
In reply to Re: confusing nomenclature, posted by Extreme on October 24, 2008, at 5:36:36
> Thank you so much Lucie for bringing some clarity to this. So histidine and other amino-acids that sits on the "lock"/receptor is part and attached in a bigger chemical system so to say... suspected something like that.
> WELL... then this leads me to thinking, as before.. how come benso "decides" when to work or not for me and what in the world is going on under extreme pressure from histamine (allergy) in my brain that seems to inactivate benso completely!
Histamine has a few different roles in the body. As you say, it can be involved in allergy but not in the brain since the antibodies (which help produce the true allergic response) are too big to cross the blood-brain barrier. But histidine (the free form, not the form making up proteins) can be made into histamine which is small enough to pass freely across the blood brain barrier. The action of histamine in this context is as a neurotransmitter, and could still (I guess) be involved in your particular reaction to certain drugs. Have you tried posting this on the neurotransmitter board?
are there any (known) conditions under which the whole polypeptide chain that "runs" the GABA-A bindingsite can change "parameter" or composition? DOES it change ever or is it attributed to a "static" DNA-sequenze?
Proteins are made up of amino acid sequences, just as genes are made up of DNA sequences. In proteins, these sequences fold up in certain ways that make a specific shape for a given protein molecule. These folded molecules can sometimes change the way they are folded but not their amino acid sequence, at least not in the way you mean. Did you have something particular in mind?
> It should be very interesting if histidine actually destoys the benso-effect completly as it is the precursor to histamine.
You should go into research, you have a healthy curiosity and a questioning mind :)
Lucie
poster:lucie lu
thread:858937
URL: http://www.dr-bob.org/babble/20081016/msgs/859136.html