Posted by Extreme on October 23, 2008, at 9:13:09
I posted this in the neurotransmittor-section:
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Some weeks ago I was trying to relieve some anxiety with oxazepam. Since some years back I have been unable to get bensos to work when I need them. My thought is that it is due to overuse from some years on benso on and off. But this thing that happened did not make sense at all.
I was on quite a high level of oxazepam, nothing really did happen, just made me feel worse (probably partly CNS-depression from oxazepam)... I got this crazy idea that I would mix it with another benso that I also use sometimes. Usually I am not into mixing bensos... I take them one at the time. I mixed oxazepam with nitrazepam and guess what happened? Total success! And I mean TOTAL LOL! Yea... enough of the "happy-benso-talk" :P
So now to the mystery... if my system was pretty fed up with benzo how in the world could a combination of two of them make the situation better? In my own thoughts AND actually expectations at the time there was the risk of it becoming worse. But hey... it gets even more complex... in the past weekend I tried nitrazepam alone (same dose)... almost nothing happened!
I cant make sense of this... how come a combination of two bensos worked but neither of them work alone? My theory again is that it is due to my overuse of them since some years... and that a combo nowdays is required to "kickstart" the process.
Anyone else in here have the same experience?
-----------------------------------------------Got no response and in the meantime I came up with the bright idea of really looking into why benso work (for the 14th time or something)! From Wiki on benso:
"Benzodiazepine binding also requires that alpha subunits (in the GABA-complex that is - my remark) contain a histidine amino acid residue"
Histidine! The most simple thought came up... what if my non-response nowdays to benso is partly overuse AND that leading to smaller amounts of histidine in the brain... because SOMETHING weird was going on in the part I wrote about... would a supplement of histidine "kick-start" the benso-binding as the fact states? I will find out... because this guinea pig just ordered L-histidine (500 mg capsules)! It SHOULD be able to cross the blood brain barrier as far as I have read about it... some substanses as you know does not, like GABA for example.
So... I will report back in a few weeks!
poster:Extreme
thread:858937
URL: http://www.dr-bob.org/babble/20081016/msgs/858937.html