Posted by Marty on September 1, 2008, at 15:22:53
In reply to Re: Getting back on Agomelatine (Valdoxon) » Marty, posted by SLS on September 1, 2008, at 14:38:31
> > > - melatonin M1 agonist
> > > - melatonin M2 agonist
> > > - 5-HT2c antagonist
> > ---
> > Hi Scott, Wouldn't Serzone/Desyrel + Rozerem more like it
> I am curious about your choices of drugs. What is your rationale? Maybe you are on to something.
Search no diamond in my rationale, there's none. I was just plain wrong: Serzone and Desyrel antagonize 5-HT2a, not 5-HT2c ... The rationale was based on the 5-HT2c antagonist assumption. If it would have been the case it would have procure the 5-HT2c antagonism with lesser SRI action than Prozac. Actually, just to point out how bad this idea was: mCPP, an active metabolite of both Nefazodone and Trazodone, act as a 5-HT2c AGONIST. A fact which explain partly the positive effect of Desyrel on libido: 5-HT2c agonism = sexual arousal. Counter intuitive if you think about the 5-HT2c antagonism strategy to get rid of the sexual side effects of the SRIs.. but I guess this is to protect 5-HT2c from overstimulation which results in desentiszation. That said, Prozac is the proof, anyway, that this strategy is somewhat overrated.
Btw, if Prozac could provide good 5-HT2c antagonism without much SRI action at small dosage (ie: 5mg) .. I wonder why I never read about trying it a this dose for SRIs induced sexual side effects. I would deal much better with a very slightly increased level of SRI than with all the unpleasant side effects coming with Cyproheptadine (ie: sex-killing sedation, increased appetite/weight gain).
> You are good stuff.
Thanks Scott. Coming from you, this compliment is quite flattering for anyone here knowing you. I may not be one of the most knowledgeable person here, but I like to think that I improve by the day.
Speaking of good stuff, thanks for this:
.. If you had 1$ every time it saved me a painful research in 'Abstracts Land', you could have enough, at least, to buy yourself a new computer. ;)