Posted by SLS on September 1, 2008, at 14:38:31
In reply to Re: Getting back on Agomelatine (Valdoxon) » SLS, posted by Marty on September 1, 2008, at 14:26:02
> > You might like to try combining Prozac with low dosages of Rozerem (ramelteon). This might approximate the pharmacodynamics of agomelatine.
> >
> > - melatonin M1 agonist
> > - melatonin M2 agonist
> > - 5-HT2c antagonist
> ---
> Hi Scott, Wouldn't Serzone/Desyrel + Rozerem more like it since Agomelatine doesn't induce SRI ? Serzone and Desyrel does.. but way less than Prozac I think... no ?
>
> /\/\artyI chose Prozac because it is an extremely potent antagonist at 5-HT2c receptors - more so than at the 5-HT transporter. One could probably get away with using 5mg. The antidepressant effect of agomelatine may very well hinge upon this property in addition to the M1 and M2 agonism it produces.
I am curious about your choices of drugs. What is your rationale? Maybe you are on to something.
You are good stuff.
- Scott
poster:SLS
thread:849568
URL: http://www.dr-bob.org/babble/20080822/msgs/849751.html