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Antipsychotic + Stimulant . Prevent tolerance?

Posted by maz81 on August 9, 2008, at 7:34:11

My pdoc has put me on 400 mg of Seroquel (quetiapine) and is planning to add Adderall to help with bipolar depression and ADHD. His logic for using an antipsychotic is to prevent hypomania.

I am wondering whether the Seroquel will block the Adderall from working as it would seem to me that they are working against each other. Although I only have a very basic understanding of psychopharmacology.

However if the combination does work, I was wondering whether the combo could prevent stimulant tolerance. I understand that dopamine antagonist such as antipsychotics increase the number of dopamine receptors and make them more sensitive to dopamine. Or maybe the two drugs just cancel each other out?

Does anyone have any experience or insights?


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