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Re: Which is superior Duloxetine or Venlafaxine ?

Posted by West on July 23, 2008, at 17:53:06

In reply to Re: Which is superior Duloxetine or Venlafaxine ?, posted by West on July 23, 2008, at 17:26:51

Or more plausibly, norepinephrine (if we are taking the term stimulating to mean noradrenergic. Any Initial euphoria could be seen as a response to extracellular dopamine increase)

From 'Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor.

Inhibition of [3H]5-HT or [3H]NE uptake by DVS for the hSERT or hNET produced IC50 values of 47.3 +/- 19.4 and 531.3 +/- 113.0 nM, respectively. DVS (10 microM), examined at a large number of nontransporter targets, showed no significant activity. DVS (30 mg/kg orally) rapidly penetrated the male rat brain and hypothalamus. DVS (30 mg/kg orally) significantly increased extracellular NE levels compared with baseline in the male rat hypothalamus but had no effect on DA levels using microdialysis.'

http://www.ncbi.nlm.nih.gov/pubmed/16675639?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

 

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poster:West thread:841535
URL: http://www.dr-bob.org/babble/20080718/msgs/841651.html