Posted by Amigan on July 23, 2008, at 14:30:42
In reply to Re: Which is superior Duloxetine or Venlafaxine ?, posted by West on July 23, 2008, at 13:57:35
> 'I haven't tried any of these meds, but i read that Venlafaxine is more energizing than Duloxetine. So, it may be a better choise for what you seek except of sleep.'
>
> I've also read this. Strange considering that venlfaxine inhibits norepinephrine and serotonin at a ratio of 1:200 in vivo, and duloxetine 1:10. I assume the stimulatory effect is down to its its belonging to the phenylethylamine class like phentermine/bupropion/amphetamine. Just goes to show that stronger affinity for NA doesn't necessarily make for a more energizing profile. On the other hand, askapatient.com has lots of people complaining of sleepiness and apathy.Yes, i find it strange too. Perhaps Duloxetine has higher affinity for histamine-1 receptors. This is the usual suspect for meds that suppose to be activating, but they are not.
poster:Amigan
thread:841535
URL: http://www.dr-bob.org/babble/20080718/msgs/841623.html