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Re: RU 486 - what happened to fast tracking?

Posted by undopaminergic on June 30, 2008, at 7:29:35

In reply to Re: RU 486 - what happened to fast tracking?, posted by SLS on June 30, 2008, at 5:01:42

> One problem with mifepristone is that it blocks cortisol receptors responsible for engaging the negative feedback loop upon the adrenal glands. Cortisol levels end up going off the charts. Not good.
> - Scott

Good point. Actually, I supect it's even worse than you suggest: mifepristone would also block cortisol receptors of the pituitary and probably the hypothalamus, thus increasing the secretion of ACTH (AdrenoCorticoTropic Hormone) and CRF (Corticotropin-Releasing Factor), respectively, and these hormones may have deleterious effects of their own - indeed, CRF-antagonists are being investigated as possible antidepressants and anxiolytics.




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