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Re: RU 486 - what happened to fast tracking?

Posted by undopaminergic on June 29, 2008, at 19:07:40

In reply to Re: RU 486 - what happened to fast tracking?, posted by SLS on June 27, 2008, at 22:31:50

Mifepristone is hypothesised to be useful against depression due to its antagonism of the glucocorticoid receptor (cortisol receptor), since cortisol is often (usually?) elevated in depression.

In my opinion, it is more sensible to lower cortisol than to attempt to antagonise it. A reduction of cortisol secretion can be achieved through the administration of opioids (morphine, methadone, buprenorphine, etc.), alpha2-adrenergic agonists (guanfacine, guanabenz, clonidine), and probably some other drugs. As an anti-depressive treatment that lowers cortisol, buprenorhpine seems an ideal choice.




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