Posted by Dopamine123 on June 20, 2008, at 21:08:49
In reply to Re: Mirapex found effective in TR Depression and B » linkadge, posted by Phillipa on June 17, 2008, at 13:03:43
I tried requip which has the same mechanism of action as mirapex. I found the cognitive side effects to be really bad. Requip tends to cause executive dysfunction because of reduced stimulation of the d1 receptors in the prefrontal cortex. The D2/D3 receptors are stimulated by the drug, but this actually reduces the amount of real dopamine in the synapse leading to a decreased activation of d1 receptors.
So my verbal fluency (ability to talk) and concentrate took a huge hit when on the drug.
poster:Dopamine123
thread:834964
URL: http://www.dr-bob.org/babble/20080617/msgs/835728.html