Posted by linkadge on June 17, 2008, at 11:32:46
In reply to Re: Mirapex found effective in TR Depression and B, posted by blueboy on June 17, 2008, at 10:03:15
>Why are dopamine agonists so novel if we already >have drugs like Nardil that have dopamine >reuptake? Many people still don't respond to >MAOIs either.
Like mentioned the side effect profile of different drugs can be different. MAOI's can cause significant insomnia for some users.
While Nardil "theoretically" should raise dopamine, some studies have not found a strong effect in this regard:
http://biopsychiatry.com/phenelzine.htm
Dopamine agonists are also selective to certain dopamine receptors. Not all dopamine agonsts have the same antidepressant effect. The d3 receptors may be implicated.
Serotonin also has inibitory actions on dopamine neurotransmission along certain neural pathways. Some people don't do well on agents that increase serotonin.
Linkadge
poster:linkadge
thread:834964
URL: http://www.dr-bob.org/babble/20080617/msgs/835048.html