Posted by undopaminergic on June 20, 2008, at 12:19:17
In reply to Re: does selegiline really mitigate DAergic cell l » undopaminergic, posted by SLS on June 15, 2008, at 5:31:51
> It is the depression that is producing your dementia. It will resolve gradually as you respond to an antidepressant treatment robustly. The degree of dementia in depression is increased as one ages with the disorder inadequately treated. In fact, melancholy seems to be replaced by dementia in the elderly, thus the errant diagnoses of what is now known as depression-induced "pseudodementia". My personal opinion is that the hippocampus loses tissue volume as the result of atrophy due to a pathological reduction in its activation by efferent pathways. To compound matters, chronically elevated cortisol also results in the loss of hippocampal tissue volume.
>Another interesting action of mu-opioid agonists is that they lower cortisol levels. In contrast, the more potent noradrenaline reuptake inhibitors, such as reboxetine and atomoxetine seem to have a strong tendency to raise cortisol, whereas the effect of methylphenidate is less pronounced, and selective serotonin reuptake inhibitors have a neutral impact, although one study reported a greater elevation of waking salivary cortisol by citalopram in comparison with reboxetine, which they claimed was indistinguishable from placebo - I wonder if they mixed up the two drugs.
> Wow!
>
> What an excellent treatise on selegiline!
>
> I don't know how you have come to possess so much knowledge, but your presentation was wonderful. I have followed the development of L-deprenyl since 1983 when it was first being developed as an antidepressant.
>
> Again, I would like to offer you praise for your post composition, as it is worded extremely well and is extremely accurate.
>Thanks for your display of appreciation, but you are exaggerating its magnificence. It leaves much room for improvement, but for a story improvised mostly from memory, it's pretty good.
> How in the world did you know about clorgyline and the propargyl class of MAOIs?
>I researched selegiline extensively many years ago, perhaps in conjunction with starting to take it regularly, first as monotherapy and later with PEA. I've updated my knowledge of it from time to time, sometimes prompted by internal or external cues, but at other times accidentally, while researching other topics. I learned about clorgyline as a side-effect of reading about selegiline and other aspects of MAO inhibition.
> Clorgyline is the most efficacious antidepressant that presently exists.
>You've said so before as well, but I'm not convinced. In the context where I read about clorgyline, it was often compared to selegiline or other drugs, and I don't recall ever being impressed with any of its effects. Even so, due to its potent monoamine oxidase inhibitory action, I don't doubt that it's an effective antidepressant when given in sufficient doses, but what makes you think it's more efficacious than other MAOIs?
> At the moment, clorgyline is no longer being manufactured for human consumption. However, as a biological probe, it is the de facto marker of MAOI-A enzyme concentration.
>I imagine clorgyline is available from multiple suppliers at high purity. If I really believed it was as good as you appear to do, I would be seeking to acquire it soon.
poster:undopaminergic
thread:834421
URL: http://www.dr-bob.org/babble/20080617/msgs/835630.html