Posted by SLS on June 20, 2008, at 4:25:03
In reply to Re: Possible Eureka., posted by bleauberry on June 19, 2008, at 21:02:08
Hi BB.
> I typed tianeptine into the search box at pubmed and clicked on a few pages of abstracts. Tianeptine appears pretty complicated and unique.
It must be to fly in the face of the putative mechanism of SRIs.
> It has something to do with neuroplasticity, modulating the inflammatory response, modulating the stress induced GABA/glutamate response,
I didn't know about the anti-inflammatory effects of tianeptine. Very interesting.
> Decreases plasma serotonin but increases platelet serotonin.
This makes perfect sense. According to my current model, tianeptine would decrease 5-HT turnover (and thus decrease plasma levels) by sequestering more of this neurotransmitter in the vesicles and making less available for cytosolic catabolism by MAO. Of course, 5-HT levels in platelets would be increased through an accelerated rate of reuptake produced by tianeptine.
> Decreases plasma noradrenaline,
This could be due to a reduction in NE turnover as would be the case with a drug that amplifies 5-HT signaling and consequently reduces NE through an indirect effect.
> Your theory SLS makes sense to me.
I thought I was the only one. I have very little emotional investment in the accuracy of my theory. I just seek understanding, regardless if my idea is wrong or right.
- Scott
poster:SLS
thread:835062
URL: http://www.dr-bob.org/babble/20080617/msgs/835604.html