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Re: Possible Eureka.

Posted by linkadge on June 19, 2008, at 8:16:41

In reply to Re: Possible Eureka., posted by SLS on June 19, 2008, at 5:40:34

>More 5-HT = Less DA?

>Less DA = DA receptor upregulation?

>Could work.

The only problem with the dopamine receptor upregulation is that it is selective to certain deep limbic regions. This is not really consistent with supersensitivity due to a widespread dopamine transmission reduction. Also, if there was a general dopamine reduction, you would expect an upregulation of *all* dopamine receptor subtypes (d1,d2,d3,d4...)

Certain other compounds with AD effect also upregulate d2/d3. Surmontil does, but it has no general effect on monoamine levels. DHEA upregulates d2/d3 receptors but there is nothing I am aware of that says it decreases overall dopamine neurotransmission.

I think I agree with Dave Pierce who suggests that this adaptive process is literally what makes the drug work.

Linkadge


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URL: http://www.dr-bob.org/babble/20080617/msgs/835423.html