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Re: Restarting Parnate

Posted by undopaminergic on June 5, 2008, at 13:54:34

In reply to Re: Restarting Parnate » Justherself54, posted by Zeba on June 2, 2008, at 22:46:38

I recommend taking Parnate in divided doses, not only to maintain alertness throughout the day, but also in order to avoid complications.

Tranylcypromine (Parnate), in addition to its MAO-inhbiting properties, has acute amphetamine-like effects that are closely dependent upon the concentration of the drug in tissues, unlike the MAO inhibition, which persists for weeks even after cessation of the drug. This has a couple of implications:

Taking a high dose of Parnate, all at once, may provoke a so-called spontaneous hypertensive reaction, and dividing the daily dose into two or more smaller doses helps avoid this complication, which has frightened a number of people into quitting the drug prematurely. This reaction only occurs with Parnate, and not with Nardil or Marplan, because these other MAOIs lack Parnate's amphetamine-like actions. Amphetaminergic complications may occur with selegiline as well, but not with rasagiline.

The other implication of Parnate's amphetamine-like action is for the time of administration. The doses should be taken at suitable times of the day in order to maintain alertness, and to avoid worsening the insomnia that is a frequent side-effect of all MAOIs, regardless of when they are taken.


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