Posted by SLS on June 3, 2008, at 4:58:42
In reply to Re: SLS - riluzole, posted by undopaminergic on June 3, 2008, at 0:40:41
Hi.
> > > Do you think a glutamate-enhancing type of AD would tend to have such effects?
> >
> > Modafinil (Provigil), a glutamate release enhancer, destroyed me. It made me very dumb and left me in a fog. It exacerbated my depression greatly.
> Your experience with modafinil is remarkable. It generally has the opposite effects on most people, although I did read of one other person who noted effects of the same character as you do, but with much less intensity.
>
> I think modafinil's glutamate enhancement is an effect downstream of its dopaminergic reuptake inhibition. Cocaine and amphetamine also increase glutamate efflux in several regions, including prefrontal cortex and nucleus accumbens, and this effect is prevented by dopamine D1- and D2-receptor antagonists.
>
> Do you react better to the other stimulants?Yes, but only for a few days.
I have a pattern with standard antidepressants such that after 2 weeks have passed, I experience a robust antidepressant response that lasts for three days. After this three day period of improvement comes a crash into my baseline (unmedicated) depression. With Dexedrine, I experience an improvement within hours of the first dose. Unfortunately, this response lasts for three days. Three days seems to be an important clue to what's going on, as my brain insists on compensating for the altered psychobiology.
Regarding my experience with modafinil, the worsening of condition lasted for at 2 weeks after discontinuing the drug.
Thanks for your feedback.
- Scott
poster:SLS
thread:726603
URL: http://www.dr-bob.org/babble/20080528/msgs/832648.html