Posted by rovers95 on January 27, 2007, at 4:47:11
In reply to Re: SLS - riluzole!!! » rovers95, posted by blueberry1 on January 26, 2007, at 16:59:20
> Hi Mark,
> Something you said caught my attention. "like ket and magnesium, has pro dopaminergenic properties due to its NMDA antagonism???"
>
> Tell me about magnesium and its connection to dopamine and NMDA. My doctor prescribed magnesium for me yesterday in order to tame down overactive glutamate. But I didn't know about pro-dopaminergic effects of magnesium. Can you explain?
>
> Thanks.
> blueberry
>
>
>
>Think this is how it works, excess glutamate at the NMDA receptors inhibits dopamine release into the nucleus accumbens (and probably other parts of the brain).
For example, magnesium deficient rats are found with normal levels of noradrenaline, adrenaline and seretonin.........but lower levels of dopamine, however if you were in this situation and you were to take something like wellbrutin you may get yourself up to the right amount of dopamine, but as this converts to adrenaline and noradrenaline - you would find yourself "over stimulated", especially with the excessive glutamate.
Therefore, plugging the NMDA receptor through magnesium prevents the release of glutamate, and appears to prevent glutamate induced damage to the D1 and D2 receptors. It also downregulates the HPA axis (the stress response).
If i was you i would use a chelated form (solgars??), and if that is innefective try IM injections as this is all that works for some people.
mark
poster:rovers95
thread:726603
URL: http://www.dr-bob.org/babble/20070125/msgs/727022.html