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Re: cholinergic med counter to nardil sex. dysfunc » iforgotmypassword

Posted by SLS on May 27, 2008, at 17:01:19

In reply to cholinergic med counter to nardil sex. dysfunc.?, posted by iforgotmypassword on May 27, 2008, at 7:06:53

> wondering if a cholinergic med may be the right route.
>
> nardil causes dry mouth by who knows what mechanism, and can cause "mental slowing". this may be an indication that somehow it throws off the cholinergic system.
>
> cholinergic meds are supposed to be "pro-sexual", somehow...
>
> cholinergic meds are: donepezil, rivastigmine (may be even more cholinergic in mechanism, needs multiple daily dosing, but so does nardil, the poster "utopizen" used a specific cholinergic drug (muscarinic receptor agonist) to counter desoxyn dry mouth. (he also took donepezil, with positive cognitive effects reported after 1 month, did not say anything about dry mouth relating to this drug, do not know if this was started before or after other drug)
>
> my message is getting long again.
>
> i may be being rx'd nardil or selegiline today. not that sexual related stuff ever really comes up in my life, it is still a concern for whatever wierd reason. and the other reported side effects of nardil make me paranoid. a huge part of my illness is cognitive dysfunction and periodic cognitive failure destroying vocational and social capacity. i do not want nardil to make days any more humiliating. (input?)


Feeling whacked-out on Nardil at the beginning of treatment is normal and may even be a sign of good things happening. My advice is to try Nardil, starting at 1/2 pill per day and move up to 1 pill after a week. You can then move up by 15mg every week until you get to 60mg. Go slower if necessary. Once you establish 60mg as your target, remain there for at least 3 weeks and assess clinical benefit and side effects. Go to 75mg if necessary and remain there for 6 weeks. If necessary, and if you are tolerating the drug, you might find that you don't hit pay dirt until you reach 90mg.

Once the true antidepressant effect emerges, you will probably find that your cognitive function will improve far beyond where it is now.


- Scott

 

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