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Re: Nardil- The best AD ever.......

Posted by undopaminergic on May 24, 2008, at 14:39:24

In reply to Re: Nardil- The best AD ever....... » ace, posted by Phoenix1 on May 23, 2008, at 12:24:38

>
> I've read a lot of your Nardil posts from the archives, and I really respect your opinions. I need your advice please. I failed to respond to over a dozen AD's until I tried Nardil. Then it was like a light bulb turned on and the depression and anxiety literally melted away. Everything was great for 7 months at 90mg.
>
> Then, out of the blue, I developed severe orthostatic hypotension which quickly turned into fainting spells. Pdoc discontinued Nardil over 7 days. 1 day after my last nardil dose, I woke up blind, paralyzed, and confused. Was diagnosed with PRES, a reversible swelling of the back of the brain caused by blood pressure fluctuation.
>
> I'm getting better neurologically now, but my depression has returned, and my pdoc will not prescribe Nardil for me ever again. He thinks it caused the PRES. I believe the quick withdrawal caused the PRES.
>

The fluctuations of blood pressure were the problem that caused PRES. A rapid elevation of blood pressure following Nardil discontinuation may have been the problem.

Taking methylphenidate with Nardil may help stabilise blood pressure, and also reduce tyramine sensitivity. However, the combination needs to be initiated with low doses and close monitoring of the blood pressure response.


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