Posted by undopaminergic on May 21, 2008, at 18:45:29
In reply to Re: Nardil- The best AD ever....... +raquo; undopaminergic, posted by ace on May 19, 2008, at 2:13:56
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> > > I would suggest Nardil with a fast titration, up to a maximum of 60mg within 2 week, if you can tolerate any s/effects. On top of that i would suggest you continue with Valium (or another benzo) at a dose required. The drug TRAMADOL can also be of benefit (on a short term basis).
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> > The use of tramadol under treatment with phenelzine (Nardil) or other potent MAOI should be approached with great caution, as the combination of monoamine oxidase inhibition with the serotonin reuptake inhibition of tramadol has the potential to precipitate the serotonin syndrome. If an opioid would be of use, codeine, oxycodone or any other drug free of serotonergic activity is safer.
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> I see what your saying here, although the combination posed no problem for myself. In addition I have seen (a few) anectodes on their combined use, and one clinical trial (which espoused the combination)
> Tramadol acted extremely with with Nardil, but as you know we are all so individual with our reactions....
> You caveat is warranted.
>Some people get rather severe reactions from the addition of a SSRI to selegiline at MAO-B selective doses, although I personally used the combination (with sertraline) without problems, and there have also been studies using these combinations; in other words, there is indeed a great deal of individual variation.
poster:undopaminergic
thread:827439
URL: http://www.dr-bob.org/babble/20080519/msgs/830395.html