Posted by JDx on April 19, 2008, at 18:32:44
In reply to Re: cognitive problems from solian, posted by undopaminergic on April 16, 2008, at 14:52:23
> > > Like you, I use methylphenidate (Ritalin, Concerta, etc.) and amisulpride (Solian), but I haven't noticed the memory impairing effect you describe.
> > >
> > > One possibility is that amisulpride and methylphenidate potentiate each other too much in some areas of the brain. In particular, the prefrontal cortex is sensitive to excessive dopamine (and noradrenaline) levels. There is evidence that alpha2A-adrenergic agonists are effective for treating such conditions. One such drug - guanfacine - has also proven useful for normalising some cognitive abnormalities in schizotypal personality disorder (a schizophrenia-spectrum disorder). Therefore, guanfacine may be worth a try (it's also good for ADHD).
> > >
> > > One study found memantine to be effective for negative (but not cognitive) symptoms in schizophrenia, so you may wish to look into that too.
> >
> > What side effects did you encountered from amisulpride? what are the daignosis your doctor perscribes you ritalin and amisulpride? anxiety and ADHD?
> >
>
> ADHD (inattentive type) and (atypical) depression. I also meet the diagnostic criteria for schizoid personality disorder, but I'm not diagnosed with it. I haven't noticed any side effects at all from amisulpride (50-100 mg), probably because I had been taking the very similar drug sulpiride before it. In the beginning of trying larger doses of sulpiride I noticed some adverse effects on motor coordination, but they went away within a week or so.
>
> >
> > i am wondring what do i have - because if i have schizophrenia, this drug was suppose to inrease my cognitive abilities.
> >
>
> That is probably true if you have psychotic symptoms such as paranoid delusions and thought disorder. However, if you only have negative symptoms such as anhedonia and lack of motivation, then antipsychotics are unlikely to improve cognition much. The stimulating properties of amisulpride at low doses (up to 100 mg or so) can help with motivation. In my experience, Ritalin is also useful for that purpose, and also improves cognition, including memory, attention and verbal skills.
>
> > and if my brain is normal , it doesn't suppose to do anything in that regard. same if i had adhd.
> > Before i started taking it i had extremly good photographic memory, i was best in my class in university and considered a genious of some kind..and now, I need to get help from other students in order to understang what is going on in classes,and i am sitting about 10 hours trying to read only a few pages in our work book=[
> >
>
> That's quite a decline. You really should try making some adjustments in doses and medications to see if you can improve the situation.
>
> Some examples:
> * try higher doses of amisulpride - it can get better or worse, but you can learn from the experience
> * try lower doses of Ritalin - you may find that you need less of it now that you take amisulpride
> * lower the amisulpride dose and take more Ritalin instead - perhaps you can get the same benefits with fewer side effects
> * try adding guanfacine - can help with memory and cognitition
> * try adding modafinil - see above
> * try replacing Ritalin with modafinil - perhaps modafinil has the same benefits but fewer side effects
> * add an anxiolytic (benzodiazepine) and lower amisulpride
> * add memantine - with and without removing one or more other drugs
> * add some lithium, oxcarbazepine or other anticonvulsants or mood stabilisers
> * etc...
>
thx, i'll try that after i will try glycine . yesterday i got the order of 1 kilo glycine, and it seem to have intersting effect. increaing cognition,memory, attetion- mybe it will replace ritalin and solian togther..I also asked yesterday my doctor what do he think i have, and he said he is not sure. He thought schizophrenia+ocd+ocpd+schizoid personality ,and he isn't sure i am adhd-ia..
About your daignosis, i think that ritalin itself can 'flatten' your motivions , and mybe thats why you feel like schizoid personality. especilly if you have adhd-ia who usually has low motivions..
i remember that when i took risperidone , it increased all my low motivions - and i felt like before i took ritlain for the first time.
It makes sens, i mean- ritalin messes with dopamine in all synapses in the brain, and not only those realated to attation, but also those which responsible for motivations
>
poster:JDx
thread:823096
URL: http://www.dr-bob.org/babble/20080412/msgs/824320.html