Posted by Amigan on March 26, 2008, at 16:05:08
In reply to Re: High blood pressure on Selegiline!, posted by undopaminergic on March 25, 2008, at 17:58:00
> >
> > > and alpha2-adrenergic agonists (guanfacine, guanabenz). I've used guanfacine, as it has been shown to improve working memory and ADHD (those benefits are more subtle, however, than with stimulants - especially in cases complicated by other symptroms such as apathy and lack of energy).
> >
> > Yes but, isn't guanfacine awfully similar to Clonidine?.. :)
>
> There are important differences that make their characterisation as "awfully similar" a definite exaggeration. For exmaple, in contrast to clonidine, guanfacine has preferential affinity for the alpha2A-adrenoceptor subtype and little affinity to imidazoline receptors. These differences may explain some of the results described in:
> http://www.nature.com/npp/journal/v21/n4/abs/1395372a.html
> http://www.nature.com/npp/journal/v20/n5/abs/1395310a.htmlI see. Ok.
> Interestingly, the EMSAM prescribing information suggests that selegiline is an alpha2B-agonist.
Never heard of it before. I don't even know what this means. I use to think that selegiline could cause hypertension due to its "catecholamine-enhancing" properties. NE enhancing in this case. I mean, Dopamine alone, can even cause a drop in blood pressure, which is consistent with what you posted earlier in this thread.
Right?
poster:Amigan
thread:819397
URL: http://www.dr-bob.org/babble/20080316/msgs/820015.html