Posted by undopaminergic on March 25, 2008, at 16:58:00
In reply to Re: High blood pressure on Selegiline!, posted by Amigan on March 23, 2008, at 15:07:57
> > and alpha2-adrenergic agonists (guanfacine, guanabenz). I've used guanfacine, as it has been shown to improve working memory and ADHD (those benefits are more subtle, however, than with stimulants - especially in cases complicated by other symptroms such as apathy and lack of energy).
> Yes but, isn't guanfacine awfully similar to Clonidine?.. :)
There are important differences that make their characterisation as "awfully similar" a definite exaggeration. For exmaple, in contrast to clonidine, guanfacine has preferential affinity for the alpha2A-adrenoceptor subtype and little affinity to imidazoline receptors. These differences may explain some of the results described in:
Interestingly, the EMSAM prescribing information suggests that selegiline is an alpha2B-agonist.