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Re: Seroquel - is it a serotonin antagonist? » jms600

Posted by yxibow on February 20, 2008, at 6:36:56

In reply to Seroquel - is it a serotonin antagonist?, posted by jms600 on February 15, 2008, at 16:36:48

> I have been reading on the net that Seroquel is a serotonin antagonist. Can, therefore, Seroquel interfere with the action of antidepressants such as the SSRIs??

Not particularly, for a variety of reasons in fact they can improve the action especially in patients with OCD.

But they work differently -- Seroquel is a blockade of multiple 5HT transmitters like Trazodone and a few other agents while SSRIs work a bit differently on the reuptake of serotonin.

Now massive amounts of all sorts of serotonin agents of course isn't the best idea and the doctor should be skilled in giving appropriate doses to avoid serotonin syndrome but in general, for example I have taken in the past 450 Luvox with 400 mg of Seroquel. As they say, your miles may vary.

 

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