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Re: Seroquel - is it a serotonin antagonist?

Posted by dbc on February 15, 2008, at 17:58:29

In reply to Seroquel - is it a serotonin antagonist?, posted by jms600 on February 15, 2008, at 16:36:48

As far as i know they dont do any sort of magic to the axion which is what makes SSRIs work. Simply dumping more serotonin into the neuronal cleft doesnt make an AD work. All Atypical antipsychotics more or less just manipulate the 5ht-2a receptor to cause dopamine levels to drop. The only current one that displays some weird anti-depressant side effect is abilify but no one is sure why.


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