Posted by kingcolon on January 26, 2008, at 23:31:17
In reply to Re: Riluzole Lamictal questions » deniseuk190466, posted by SLS on January 18, 2008, at 8:44:47
> Hi Denise.
>
> For me, the addition of riluzole to Lamictal was not at all helpful. The only impact it made was on my precription plan. It is prohibitively expensive.
>
> I don't want to get too theoretical here, but riluzole and Lamictal impact glutamatergic neurons in opposite ways.
>
> 1. Lamictal - glutamate release inhibitor.
> 2. riluzole - glutamate release enhancer.
>
>
> I don't know whether these seemingly opposite mechanisms would effectively prevent a response.
>
> I don't want to guarantee that the combination of these two drugs will produce no response or interact in ways that might actually make some people feel worse.
>
>
> - Scott
>
> My reading about riluzole seems to indicate that it is an antiglutamatergic agent, not a glutamate enhancer, similar to Lamictal. This is from the article below:Consistent with a model of excessive glutamate-induced excitation in mood disorders, several antiglutamatergic agents, such as riluzole and lamotrigine, have demonstrated potential antidepressant efficacy.
poster:kingcolon
thread:807367
URL: http://www.dr-bob.org/babble/20080124/msgs/809114.html