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Selegiline or Moclobemide? - Help me decide

Posted by amigan on December 3, 2007, at 13:30:57

Hello everyone.
I didn't got any feedback on this subject in the previous thread, thus i thought to open a separate thread about this. I guess it's because Moclobemide has not been approved in the usa. :-D

Condition: I don't suffer from depression. I have social phobia, agoraphobia and i'm somewhat dysthymic.
Treatment: I'm currently taking Diazepam + Fluoxetine (Prozac).

The benzo is ok but i am... not sure that Prozac does much for me, so i want to try a MAOI.
I know that Nardil is the right MAOI for SP etc, but it's not available in here. Not even Parnate.
I have to chose between Selegiline (Deprenyl) and Moclobemide (Aurorix). Which one do you think that it would be most effective for phobias?

Also which of the two is the more activating medication?
Diazepam make me drowsy and i could use some up-lifting. I suspect that it's Moclobemide, as it's a MAOI-A and it boosts Epinephrine+ NorEpinephrine+ Dopamine!, (Serotonine is not activating) while Selegiline only boosts dopamine at <=10mg... Right?
On the other hand, Selegiline is metabolized into L-(meth)Amphetamine, BUT i read that the l- isomer is not considered to be psychoactive at all! It has only peripheral action.

PS: Another question sprung to mind since i've being digging this forum to find some answers to my questions: Why almost everyone here, writes (more or less) that Moclobemide is cr*p, while there so much excitement for Selegiline? "On paper", Moclobemide looks so much better. (see above info) There is got to be a reason. Perhaps Selegiline does some additional stuff that i'm not aware of?

Thank you.


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poster:amigan thread:798497
URL: http://www.dr-bob.org/babble/20071125/msgs/798497.html