Posted by Larry Hoover on August 21, 2007, at 19:47:03
In reply to Re: SSRIs and bone loss, posted by linkadge on August 21, 2007, at 19:37:22
> Did they comapre those treated with AD's to age matched depression sevarity matched drug free controls? (I didn't read all of above data). Ie to exclude the possability that depression itself isn't the cause of the bone loss?
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> LinkadgeThe study of older females did use factor analysis to control for confounders, including and excluding depression. It didn't seem to make a difference.
"After adjustment for potential confounders, including the Geriatric Depression Scale score, mean total hip BMD decreased 0.47% per year in nonusers compared with 0.82% in SSRI users (P<.001) and 0.47% in TCA users (P=.99). Higher rates of bone loss were also observed at the 2 hip subregions for SSRI users. Results were not substantially altered when women who scored at least 6 on the Geriatric Depression Scale were excluded from the analysis."
The data for males were not corrected for depression. Yes, depression may be a true confound, notwithstanding the lack of significant effect of depression in the female cohort.
Lar
poster:Larry Hoover
thread:777598
URL: http://www.dr-bob.org/babble/20070815/msgs/777662.html