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Re: SSRIs and bone loss » Quintal

Posted by Larry Hoover on August 21, 2007, at 17:42:33

In reply to Re: SSRIs and bone loss » Larry Hoover, posted by Quintal on August 21, 2007, at 17:23:13

> >I'd have speculated on the orthostatic hypotension and heart rhythm disturbances associated with tricyclics....
>
> Well I suggested another two there to add to your list.

Lots of reasons to wobble.

> >On reading the abstract, I don't see anything about mechanism.
>
> True, such a statement would not stand in a court of law, but I hoped it would suffice to convey my meaning on a message board. Please forgive my vagueness, I am a little impaired at present.

Sorry. I wasn't meaning to sound picky. I just didn't see what you meant.

> From what I gather the secondary-amine TCAs nortriptyline and desipramine have less affinity for the serotonin transporter than tertiary-amine TCAs, yet in this study they correlate with a higher incidence of hip fracture than the tertiary-amine TCAs, unless I read the results backwards. So this would imply some other causal factor besides the serotonin transporter?
>
> Q

I don't know. And I've spent my frail capacity for today. I can no longer think clearly. Let's see what others can add to this understanding.

Lar

 

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poster:Larry Hoover thread:777598
URL: http://www.dr-bob.org/babble/20070815/msgs/777635.html