Posted by linkadge on August 12, 2007, at 8:56:42
In reply to Re: Vicodin and Percocet for Depression » clubfitter, posted by Quintal on August 11, 2007, at 20:59:57
There are other effects that opiates have on the brain other than the direct effects of opiate receptor agonism. For instance, opiates appear to increase the activity of tryptophan hydroxylase for the duration of exposure. Its not that tollerance won't built to certain effects of the drug such as euphoria, but researchers don't as of yet fully inderstand the complexities of neurotransmitter systems affected to a degree necessary to conclude that those who claim a long term antidepressant effect are misguided.
Case studies have observed certain treatment resistant patients gaining relief of depression for more than a year with a steady dose (monotherapy).
Its about knowing how you respond.
**One size fits all in psychiatry went out a long time ago**
Linkadge
poster:linkadge
thread:775567
URL: http://www.dr-bob.org/babble/20070808/msgs/775703.html