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Re: Nardil sleep quality

Posted by Sentience on July 3, 2007, at 10:16:11

In reply to Re: Nardil sleep quality, posted by sobeit on July 3, 2007, at 0:38:28

Hi Sobeit.

I had been on Nardil for 17 years until Feb 2007 when I decided to discontinue treatment. It took 3 months of very slow titration off the drug and I've now been completely free of all medication for 2 months. My experience with Nardil in relation to sleep, has to be split up into the time during the pre-2003"old Nardil " and the post 2003 "new Nardil"


I was on a 45 mg/day dose. I actually felt much better on higher doses of say 60 and 75 mg of Nardil, but at these levels the side-effects were intolerable and I found that 45 mg was the optimal dose of benefit/cost trade-off

Original pre-2003 Nardil

I found that the 'kick' of the dose would usually kick in around 4 hours after taking it. (this agrees well with the peak plasma levels being observed at the 4 hour point in the literature, that I later read about)

As I find Nardil to be a very stimulating & energising drug, and I was experiencing very slow sluggish mornings prior to Tx, I decided to take the 45 mg as a single dose the last thing at night before going to bed. As I usually retired around 1:00 am, it meant that the peak effect was kicking in while I was fast asleep around the 5:00 am mark. I would awaken around 7:00 am and literally JUMP out of bed full of energy.

New post 2003 Nardil

Unfortuately, with the new Nardil, I was beginning to experience more side-effects and the benefits had lost a lot of their edge too. I was now feeling the 'kick' of the dose around 1.5 hours after taking it, and it had much less "kick" in it. I was awakening earlier, and not feeling as energised as I used to. Sleep onset was becoming a problem and to make things worse, I was developing gastric pain about 20 minutes after laying down to sleep at night. After much investigation, I was able to work out that it was due to increased gas. I began to feel very sleepy during the day, particularly in the afternoon. Overall I was feeling less energised, more irritable and sleep problems were starting to dominate my life.

These issues made me decide to discontinue the Nardil. Its been 5 months since I began the withdrawal process and now my sleep has returned to 'normal'


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