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Re: Nardil sleep quality

Posted by zeugma on April 14, 2004, at 13:46:39

In reply to Re: Nardil sleep quality, posted by King Vultan on April 14, 2004, at 12:47:14

Todd/KV's guess is correct, that SSRI's suppress both REM and SWS (slow wave sleep) leading to easy arousal and also for the tendency for dreaming to 'migrate' to lighter stages of sleep where they are easy to recall.

I am not sure about the effect of dopamine on sleep, but norepinephrine appears to be the neurotransmitter that most directly regulates REM: the locus coeruleus must cease firing for the brain to enter a REM state, and selective NE reuptake inhibitors block REM without also blocking SWS.

I read a study which said that Nardil did not interfere with SWS. This would present a strong contrast with SSRI's, and is one reason why I believe MAOI's (and TCA's) to be far superior medications for the long term treatment of depression.


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URL: http://www.dr-bob.org/babble/20040412/msgs/336341.html