Posted by linkadge on May 21, 2007, at 7:35:30
The Wistar Kyoto rats are used as an animal model of depression since they are hyper responsive to stress, and they give up very easily in swim tests etc.
The interesting thing about these rats is that they *don't* show behavioral response to SSRIs or TCA's like other animal models.
Anyhow, it was interesting to come across a study suggesting an antidperessant effect of nicotine in this strain of rats. A point to possable cholinergic dysfunction.
http://www.eurekalert.org/pub_releases/2002-04/foas-nsa041602.php
Linkadge
poster:linkadge
thread:758554
URL: http://www.dr-bob.org/babble/20070509/msgs/758554.html