Posted by Quintal on May 5, 2007, at 13:30:23
In reply to Re: If MAOIs fail, what then?, posted by FredPotter on May 3, 2007, at 23:28:13
>If Nardil (or Parnate) poop-out isn't it wise to increase the dose? However, I read that after 4 weeks of effective response one can drop the dose right down, as all the MAO has been destroyed and it takes a long time to be restored so a small dose is all that is needed to mop up the new MAO as it is created.
With Nardil you have active metabolites like phenylethylidenehydrazine that increase GABA and they very likely play an important part in the therapeutic response. Lowering the dose would lower the level of these metabolites so it might be unwise to assume it's okay to lower the dose once you've achieved a remission going purely by the MAO theory.
With Parnate you have those rumours of amphetamine metabolites which I think play an important role at high doses, yet my pdoc refused to raise the dose beyond 30mg and hoped to reduce it to 10mg as a maintenance dose. I'm sure that would not have worked.
Q
poster:Quintal
thread:755424
URL: http://www.dr-bob.org/babble/20070502/msgs/756074.html