Posted by linkadge on March 31, 2007, at 13:35:14
In reply to Re: Dopamine Agonists » rvanson, posted by Quintal on March 30, 2007, at 21:20:13
>Alternatively dopamine agonists may not induce >euphoria, and if so why not, when they simulate >dopamine release - or am I mistaken in thinking >this? What is so different about the action of >dopamine agonists compared to say, a transport >blocker like Ritalin that would make them less >likely to induce euphoria?
Not all dopamine reuptake inhibitors produce euphoria. For instance clinical doses of SJW produce a >50% inhibition of dopamine trasporters but produces no euphoria, probably owing to lack of effect on dopamine uptake in neucleus accumbens. Some other investigaitonal DRI's also show little affinity for NAA dopamine transporters.
It depends on the brain region involved. Dopamine agonists do not necessarily bind with high affinity to reward regions wherase a non region specific DRI will activate such regions.