Posted by rvanson on March 30, 2007, at 19:39:26
In reply to Dopamine Agonists, posted by Quintal on March 30, 2007, at 10:34:01
> I've just taken my first 0.125mg dose of Mirapex (pramipexole) and so far so good. I feel warm and comfortable, calm, a little bit light-headed and a leetle beet horny.......... It's reminiscent of my last trial of amisulpride, which worked well for me for two months and I'm hoping for more success with Mirapex.
>
> I few questions that keep bugging me I'd like to throw to the general audience;
>
> * Can dopamine agonists produce euphoria?Yes, but not often.
> * If so, why aren't they scheduled and controlled like similar drugs that simulate dopamine release? I'm thinking that it might be that drug addicts haven't caught on to this yet and that dopamine agonists are rarely prescribed, and then only for serious conditions in which the sufferer is unlikely to sell their medication for profit. It seems unlikely that Big Brother FDA hasn't cottoned on to this 'risk' though.<<Give them time. They can only pass so many unneeded laws each year !
> * Alternatively dopamine agonists may not induce euphoria, and if so why not, when they simulate dopamine release - or am I mistaken in thinking this? What is so different about the action of dopamine agonists compared to say, a transport blocker like Ritalin that would make them less likely to induce euphoria?Cant say, as I am not a chemical/biological scientist, except that Ritalin affects the NE system as well, if I recall correctly.
> * Why are they associated with drowsiness and sudden onset of sleep when dopaminergic drugs are usually stimulating?I never had that effect with them but nuasuea is common enough.
> * Many people seem to complain of short attention span and apathy with pramipexole. I'm wondering if the addition of reboxetine would help with this and also bolster the antidepressant effect?
It could for some. My expericence with Reboxetine is not a good one. If you have anxiety, it will increase it, in most cases, much like we see with EMSAM.
> * Dependence, addiction, tolerance and withdrawal syndrome. The four evils normally associated with powerful dopaminergic drugs - how do dopamine agonists compare to others in this respect?I never experienced much withdrawal off of these medications.
Nothing like Paxil or Effexor withdrawal at all.
poster:rvanson
thread:745429
URL: http://www.dr-bob.org/babble/20070327/msgs/745609.html