Posted by circusboy on February 23, 2007, at 8:08:38
In reply to Re: Does Lamictal plus cholinergic make sense?, posted by Joe Bloe on February 23, 2007, at 0:27:37
It's important to note that -- in spite of our experience with nicotine -- the worst anticholinergics in terms of cognitive effects seem to preferentially block *muscarinic* acetylcholine receptors. Also, that many people can adjust to mild (e.g. desipramine) to moderate (nortriptyline) anticholinergics without too many ill effects. SLS, for instance, takes (took?) a bunch of nortriptyline and he's still pretty damn sharp. :)
From my experience so far with Lamictal, it feels more like a mild anticholinergic, like desipramine. And desipramine is a drug I might have stayed on (if it hadn't interrupted my sleep so terribly by putting my heart into overdrive at night).
[I also have a pet wild hypothesis that desipramine likes the nicotinic receptors better, since I had very mild cognitive effects on it and serious urinary retention/constipation issues, while I had practically no physical effects from nortriptyline but MAJOR cognitive ones].
-cb
poster:circusboy
thread:734880
URL: http://www.dr-bob.org/babble/20070219/msgs/735320.html