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Lamictal plus cholinergic--in theory yes, I think » Joe Bloe

Posted by psychobot5000 on February 23, 2007, at 0:43:42

In reply to Re: Does Lamictal plus cholinergic make sense?, posted by Joe Bloe on February 23, 2007, at 0:27:37

I agree that this is interesting...especially as it -conceivably- makes it possible to avoid Lamictal's side-effects.


>Now, if Lamictal is anticholinergic, (and if the primary therapeutic action of Lamictal is its anticholinergic effect, then does taking cholinergic drugs and supplements potentially mitigate any benefit from Lamictal?
>

Well, maybe. But it seems to me possible (assuming Lamictal is actually anticholinergic, of course) that Lamictal might have antinicotinic/anticholinergic side-effects (the cognitive ones), while its theraputic effect is caused by something else. While Lamictal is definitely not well understood (and may not have long term mood-benefits, lets not forget), researchers seem to believe its effects on the GABA and glutamate systems are likely responsible for its mood effect.

> Or does Lamictal have other therapeutic properties that makes it worthwhile to take the drug while trying to limit it anticholinergic properties?


Maybe so? It seems to me a perfectly good idea to at least -try- aricept (or another cholinesterase inhibitor) as an antidote to the thinking issues--It would certainly help us learn something, I think, if that worked. For me, psychostimulants were unhelpful, but maybe (?) something increasing Acetylcholine would act more directly?

I would like to remind anyone reading this that some people seem to believe cholinesterase inhibitors can lower one's mood or cause depression. I don't know how real the possibility is.

Best,
Psychbot


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