Posted by notfred on February 15, 2007, at 22:30:17
In reply to Re: Lamotrigine info requested » notfred, posted by Quintal on February 15, 2007, at 20:37:15
> Which monograph are you referring to notfred? Could you provide a link?
>The GlaxoSmithKline monograph.
http://www.crazymeds.org/lamictalpi.pdf
Lamotrigine had a weak inhibitory effect on the serotonin 5-HT3 receptor (IC50 = 18 μM). It does
not exhibit high affinity binding (IC50>100 μM) to the following neurotransmitter receptors:
adenosine A1 and A2; adrenergic α1, α2, and β; dopamine D1 and D2; γ-aminobutyric acid
(GABA) A and B; histamine H1; kappa opioid; muscarinic acetylcholine; and serotonin 5-HT2.
Studies have failed to detect an effect of lamotrigine on dihydropyridine-sensitive calcium
channels. It had weak effects at sigma opioid receptors (IC50 = 145 μM). Lamotrigine did not
inhibit the uptake of norepinephrine, dopamine, or serotonin, (IC50>200 μM) when tested in rat
synaptosomes and/or human platelets in vitro
poster:notfred
thread:733077
URL: http://www.dr-bob.org/babble/20070213/msgs/733197.html