Posted by linkadge on January 11, 2007, at 20:10:08
In reply to Re: pergolide, cabergoline: heart pathology via 5- » linkadge, posted by SLS on January 11, 2007, at 16:49:06
>"Although 5-HT1B receptors mediated the 5-HT–>induced collagen secretion by human cardiac >myofibroblasts, the contribution of this >receptor type to valvulopathy was ruled out >because double-KO mice deficient in both 5-HTT >and 5-HT1B receptors showed the same cardiac >alterations as 5-HTT-KO mice."
This says that the vulvopathy is not dependant on 5-ht1b receptors. It doesn't say, however, that 5-ht2b receptors might not be involved.
I think the reason that they started to study these mice was because somebody must have been wanting to know whether pharachological manipulation of the human transporter could affect cardaic function.
There are differences, of course, between 5-htt knockout mice, and people treated with SSRI's. Nevertheless, SSRI's can bring a person pretty close to 5-htt knockout. I remember reading that theraputic doses of sertraline inhibed 5-htt by ~80%.
So, I think there is a possability, and I think only time will tell.
Linkadge
poster:linkadge
thread:720797
URL: http://www.dr-bob.org/babble/20070107/msgs/721484.html