Posted by Lindenblüte on October 25, 2006, at 8:19:50
In reply to Re: seroquel... » ed_uk, posted by SLS on October 22, 2006, at 9:31:18
> I was half-considering giving Seroquel another try. What you are saying has me a little concerned, though. Unfortunately, it almost makes sense that it can happen. Seroquel must be hopping on and off just about every D2 receptor there is. I don't know the details of what actually prompts upregulation, but perhaps this is relevant.
>
> I know someone who is getting a real nice antidepressant effect from Seroquel. I tried it for about a week, but didn't like the irritability it produced. I wasn't real good about giving medication a fair trial at that point in time.
>4 weeks ago, my pdoc increased my seroquel from 50 mg, which I was using mainly to fall asleep, up to 300mg (titration took 10 days). Now I'm starting my 3rd week at 300mg.
The main symptoms I had prior to the increase included flashbacks, really strong startle reactions, intrusive thoughts, and acute dysphoric episodes where incidents from my childhood would come back to me flooding me in a panic of anxiety, where I just wanted to die, but I was paralysed. After such an episode, I felt like I had a bad hangover for a day or three, until the next episode.
In spring I had major depression. am taking 90mg cymbalta, which helped lift the depression. Therapy, however had taught me that feelings and emotions are okay, and that I could feel "safe" to feel and express emotions. Oops- once I opened the floodgate, I started "feeling" emotions in response to situations that I had never allowed myself to feel as a child. Hence the flashbacks, dysphoria.
pdoc upped my seroquel. No more intrusive thoughts. No more flashbacks. (well- these are about 96% reduced. Seriously, though. A miracle. I also have klonopin .5mg, which I may or may not take if I'm being triggered by something which may bring back bad feelings. I haven't really needed this but twice since I have reached the "therapeutic" dose of seroquel. Without the acute dysphoria/panic/dissociative episodes, I am feeling much better, able to be around people more, and don't feel so much anxiety or depression.
BOLDER 2 Study shows potent and fairly fast-acting AD effect of seroquel on bipolar depression (which is not my Dx, by the way). I've posted links before. in a hurry to find them again. sorry.
Linkadge, nice to see you around. I hope all is well. And I haven't been on this board in a week or two at least. I'm glad to have something to add.
-Li
poster:Lindenblüte
thread:696107
URL: http://www.dr-bob.org/babble/20061020/msgs/697571.html