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Re: seroquel... » ed_uk

Posted by SLS on October 22, 2006, at 9:31:18

In reply to Re: seroquel... » med_empowered, posted by ed_uk on October 19, 2006, at 16:18:59

Hi.

> >I seem to recall reading that seroquel has a tendency to induce dopamine supersensitivity (more so than other atypicals, I guess). I forget the mechanism..something about loose binding mixed with a short half-life

> I've read something similar. I think it was saying that people tended to relapse particularly rapidly when Seroquel was discontinued and that tolerance sometimes developed to its antipsychotic efficacy.


Did you see this stuff on the Internet?

I was half-considering giving Seroquel another try. What you are saying has me a little concerned, though. Unfortunately, it almost makes sense that it can happen. Seroquel must be hopping on and off just about every D2 receptor there is. I don't know the details of what actually prompts upregulation, but perhaps this is relevant.

I know someone who is getting a real nice antidepressant effect from Seroquel. I tried it for about a week, but didn't like the irritability it produced. I wasn't real good about giving medication a fair trial at that point in time.


- Scott

 

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URL: http://www.dr-bob.org/babble/20061020/msgs/696704.html