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Re: ATAXIA.. with klonopin/buspar/lyrica » zeugma

Posted by Lindenblüte on October 23, 2006, at 9:10:31

In reply to Re: ATAXIA.. with klonopin/buspar/lyrica » Lindenblüte, posted by zeugma on October 23, 2006, at 4:40:16

> interestingly, Provigil seems to be particularly effective in cerebral palsy, including cases in which walking was all but impossible prior to provigil use.
> The cerebellum receives extensive inputs from the vestibular system which regulates balance. Provigil also reduces GABA levels (though not sure if it does so specifically in the cerebellum), while both alcohol and benzodiazepines potentiate GABA (and benzos do so with varying potencies in the cerebellum). That could be the mechanism by which these drugs have opposing effects on ataxia.
> -z

Very cool- thanks for the info. I love the cerebellum. It's my favorite part of the brain. the gorgeous purkinje cells. the mossy fibers, the fact that the majority of the body's neurons are a single class of neurons in the cerebellum (granule cells)-- well, it all points to how challenging locomotion and motor coordination is, and how elegantly nature has met this challenge.

never been on provigil and alcohol simultaneously, however, I *have* experienced klonopin and provigil simultaneously [but I failed to pay attention]. I will pay more attention to gross and fine motor skills next time life demands this particular combination of drugs.





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