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Re: ATAXIA.. with klonopin/buspar/lyrica » Lindenblüte

Posted by zeugma on October 23, 2006, at 4:40:16

In reply to Re: ATAXIA.. with klonopin/buspar/lyrica, posted by Lindenblüte on October 20, 2006, at 11:41:04

interestingly, Provigil seems to be particularly effective in cerebral palsy, including cases in which walking was all but impossible prior to provigil use.

The cerebellum receives extensive inputs from the vestibular system which regulates balance. Provigil also reduces GABA levels (though not sure if it does so specifically in the cerebellum), while both alcohol and benzodiazepines potentiate GABA (and benzos do so with varying potencies in the cerebellum). That could be the mechanism by which these drugs have opposing effects on ataxia.





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