Posted by Squiggles on October 6, 2006, at 17:38:13
In reply to Re: Imipramine vs. Desipramine for Melancholic Dep, posted by SLS on October 6, 2006, at 17:31:48
> > Desipramine is weaker; imipramine is the
> > strongest for major depression;
>
> I agree.
>
> Of the tricyclics, though, clomipramine (Anafranil) has it beat.
>
> Both drugs can leave one feeling a little stupid. The anticholinergic properties produce some cognitive impairments in some people. I feel a cognitive dulling with imipramine, but it is tolerable. Of course, there is some speculation that the anticholinergic effects of these drugs might be contributing to their antidepressant effects.
>
>
> - Scott
I don't know much about the anticholinergic
effect-- just some snippets, like it decreases
histamine reaction, represses the urinary urge,
flattens or delays response to stimulii;If anifranil is really good (in the sense
of being 'cleaner', then i would guess that
an adjunct drug with it might be good for
major depression.Major depression is very hard to treat. But
i recall reading something interesting by
Dr. Goodwin-- that recently a reassessment
of depression is taking place, i.e. that
manic depression, schizophrenia, etc. -- all
the affective disorders may respond to similar
drugs, which were once considered specific.
I hope i am not misparaphrasing him (this is
from memory of a recent conference in Scotaland--
i think that is the paper he presented).Squiggles
poster:Squiggles
thread:692126
URL: http://www.dr-bob.org/babble/20061003/msgs/692481.html