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Re: Tonight I don't feel that antidepressants work

Posted by SLS on September 18, 2006, at 17:44:45

In reply to Re: Tonight I don't feel that antidepressants work, posted by SLS on September 18, 2006, at 16:56:53

> > Here is a good artle. A little lengthy, but it discusses many of the considerations of determining the real effectiveness of antidepressant medications.
> >
> > http://www.findarticles.com/p/articles/mi_m1175/is_n5_v28/ai_17382257/pg_1
> >
> >
> > One particular point I liked was that when a survey of the studies involving imipramine were reduced to those which were compared to active placebo (ie placebo with side effects) the active drug margin is almost completely abolished.
>
>
> I don't know what to tell you, Linkadge. I can see right through most of the arguments presented in this article. I find them specious. I am familiar with them, and am also familiar with the material that has proven them wrong,

I guess this means that I am supposed to do exactly that - prove them wrong.

Well, I think maybe I'll do that some time when these authors actually cite the literature they allude to when they make their arguments. I might then be tempted to invest what little energy I have to work with.


Example: Page 1

When I searched Medline, I found only the title of the Kane and Lieberman study they spoke of. They couldn't even bother to provide that. The abstract was not available. "The efficacy of amoxapine, maprotiline, and trazodone in comparison to imipramine and amitriptyline: a review of the literature." First of all, amoxapine, maprotiline, and trazodone had been out for less than a few years and really suck as antidepressants. Then, they have the impudence to say that "When we examined the data..." for themselves, and opine as to their significance. In other words, they say they evaluated the data on their own, and do not refer to the authors' original conclusions!

Yeah. Right.


- Scott

 

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