Posted by linkadge on August 28, 2006, at 16:22:01
In reply to Re: Dopaminergic-based pharmacotherapies for Depre, posted by Tom Twilight on August 28, 2006, at 4:42:21
Amineptine was a very promising drug too. I heard that in several animal models of depression, that it relieved symptoms faster and more completely than imipramine.
Even the SSRI's and TCA's work down the road through a dopaminergic mechanism. You can abolish the antidepressant effect of SSRI's and TCA's by reducing activity at certain dopamine receptors. For non responders, that adaptive process probably never occurs.
It doesn't make a whole lot of sence to me. Doctors insist that depression can't resolve overnight, but even some of the most severe depression can remit very quickly with the right (illegal) drug.
I'm willing to bet that even the most severly depressed people would go into a (temporary) remission if given ecstacy.
Unless there is a change in thought about how to treat these disorders, theres not going to be much process.
Researchers want a silver bullit that they never find.
So, they take amineptine off the market for a small abuse potential, but why don't they work harder at regulating the drugs instead of banning them alltogether for people who could benifit?
Linkadge
poster:linkadge
thread:680536
URL: http://www.dr-bob.org/babble/20060825/msgs/680895.html