Posted by linkadge on June 20, 2006, at 17:30:46
In reply to Re: SSRIs » Tomatheus, posted by linkadge on June 20, 2006, at 17:19:29
There have actually been some theories as to some of the possible targets for opiates in mood disorders.
Opiates may kill pain in one area of the brain, create euporia in another, and perhaps regulate certain substances in the emotional regulating parts of the brain.
You've got the TCA's which have effects on opiates in certain limbic regions. Thats why they can be used in certain pain syndromes. Perhaps more selective opiate targets would provide an antidepressant effect without activating the pleasure centres of the brain directly.
With substance P inhibitors (NK-1?) antagonists, I suppose researchers are trying to tease appart some of these effects. Perhaps limbic regulation of substance P is a target. Perhaps interaction with other neuropeptides (ie neuropeptidy Y which has marked antidepressant effect) could be responsible.