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Re: Serotonin Syndrome Reaction

Posted by SLS on June 15, 2006, at 10:00:47

In reply to Re: Serotonin Syndrome Reaction » SLS, posted by silvercoin on June 15, 2006, at 8:37:51

> > > However, if a particular individual happens to be vulnerable to serotonin syndrome propagating through the 1A receptor, adding an agent such as Risperdal can actually worsen the situation because blockading the 5-HT2A receptor reinforces the gene expression on 1A.

> > Is there a latency between the time the 5-HT2a receptors are antagonized and the reinforced expression of 5-HT1a? In your estimation, should cyproheptadine be used as an antidote to SS?

> Obviously, there must be some kind of latency, but I don't know if it's a matter of minutes or days, probably hours, but you would have to ask a psychopharmacologist to be sure. The key to being an effective SS antidote is the ability to blockade both 5-HT1a and 5-HT2a receptors. I believe that cyproheptadine does blockade 2a, but I have no idea if it blockades 1a. If it antaogonizes both and does not also blockade serotonin reuptake, this could very well be a good choice to treat serotonin syndrome with.

Out of desperation, I once foolishly tried a small test dose of venlafaxine while taking Parnate. Serotonin syndrome appeared within 1/2 hour. I was delerious and unable to sit or stand for over an hour. Luckily, I did not have a fever.


- Scott

 

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