Posted by silvercoin on June 15, 2006, at 8:37:51
In reply to Re: Serotonin Syndrome Reaction, posted by SLS on June 14, 2006, at 17:37:25
> > However, if a particular individual happens to be vulnerable to serotonin syndrome propagating through the 1A receptor, adding an agent such as Risperdal can actually worsen the situation because blockading the 5-HT2A receptor reinforces the gene expression on 1A.
>
> Is there a latency between the time the 5-HT2a receptors are antagonized and the reinforced expression of 5-HT1a? In your estimation, should cyproheptadine be used as an antidote to SS?
>
>
> - Scott
>Obviously, there must be some kind of latency, but I don't know if it's a matter of minutes or days, probably hours, but you would have to ask a psychopharmacologist to be sure. The key to being an effective SS antidote is the ability to blockade both 5-HT1a and 5-HT2a receptors. I believe that cyproheptadine does blockade 2a, but I have no idea if it blockades 1a. If it antaogonizes both and does not also blockade serotonin reuptake, this could very well be a good choice to treat serotonin syndrome with.
Todd
poster:silvercoin
thread:655417
URL: http://www.dr-bob.org/babble/20060610/msgs/657191.html